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Office 2010 - Excel prompts "The office File Validation feature has blocked this file from opening as it may contain harmful content"

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The Excel Application opens a Windows with OK button. Reading Office has detected a problem with this file. To help protect your computer this file cannot be opened.
This only happens when opeining the Excel File via a XenApp Published Application but otherwise on, Excel Installed Desktop opens the file but with a warning RED bar on top.
Opening a RED bar is good with us. but completely unable to open is the problem. See below screenshots

Any help?

Note: I have already posted this question in Answers


Always a learner


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