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"there was a problem sending the command to the program" Excel 2010

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Hello,

We are having an issue with one of our Server 2012 R2 terminal server collections.

Everything is working fine except for the mentioned error above. This error occurs when double clicking an excel document. You then get the error message and excel starts without opening the document. If you double click the document again it opens. The same thing happens naturally if one were to open excel first then the document. 

What we have tried so far:
Ignore other applications that use Dynamic Data Exchange (DDE) mentioned here: http://support.microsoft.com/kb/211494/en-us
Making sure excel does not run as administrator and/or any type of compatibility mode.
Re-installing the Office suite.
Checked some registry settings that concerns how excel. Do not remember excatly where these was located, but they checked out according to the post I found about them.

Basically we have tested most if not all things that have been discussed about this issue in other forum posts.

Lets begin there. I will add any additional required information about this issue.

Appreciate any assistance I can get on this matter.



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